🔬 What is the Test?
The Acute Leukemia Comprehensive Diagnostic Panel (ALL) is an advanced molecular and genetic test used to detect Acute Lymphoblastic Leukemia (ALL). It analyzes genetic mutations, chromosomal abnormalities, and immunophenotypic markers to confirm diagnosis, classify leukemia subtypes, and guide treatment decisions.
📊 Normal Ranges:
No detectable ALL-related mutations or abnormalities → Normal (No ALL detected)
Presence of genetic markers/mutations → Indicates ALL, requiring further clinical evaluation
(Results should be interpreted alongside other clinical and laboratory findings.)
🎯 Purpose of the Test:
✅ Confirms the presence of ALL and determines leukemia subtype
✅ Identifies key genetic alterations like BCR-ABL1 (Philadelphia chromosome), KMT2A rearrangements, ETV6-RUNX1 fusion, TP53, and JAK mutations
✅ Helps in risk stratification and prognosis assessment
✅ Guides personalized treatment plans (chemotherapy, targeted therapy, or immunotherapy)
✅ Monitors minimal residual disease (MRD) and relapse risk
🩺 When is it Recommended?
🔹 For patients suspected of having ALL (unexplained fatigue, frequent infections, bruising, abnormal blood counts)
🔹 To classify leukemia subtypes for optimal treatment
🔹 To assess relapse risk and long-term prognosis
🔹 To track disease progression and treatment response
📝 How is the Test Done?
1️⃣ Sample Collection – Blood or bone marrow sample is taken.
2️⃣ Laboratory Analysis – Techniques like Flow Cytometry, PCR, Karyotyping, and Next-Generation Sequencing (NGS) detect genetic markers and abnormal proteins.
3️⃣ Result Interpretation – Determines ALL classification, prognosis, and treatment strategy.
⚠️ What Do Abnormal Results Mean?
📉 No ALL-Related Abnormalities Detected:
ALL may not be present, or additional tests may be required
📈 Presence of Genetic Markers:
Confirms ALL diagnosis and determines subtype
Identifies standard vs. high-risk leukemia
Helps in choosing the most effective treatment approach
📌 Infographic Design Idea:
✔ Medical color scheme (blue, white, and red)
✔ Illustration of leukemia cells and genetic markers
✔ Flowchart explaining ALL diagnosis and treatment pathways
✔ Table summarizing key ALL mutations and their clinical significance