🔬 What is the Test?
The ALL Characterization Panel is a comprehensive molecular and genetic test used to analyze specific mutations, chromosomal abnormalities, and immunophenotypic markers in Acute Lymphoblastic Leukemia (ALL). This test helps in classifying ALL subtypes, guiding treatment decisions, and predicting prognosis.
📊 Normal Ranges:
No detectable ALL-related genetic abnormalities → Normal (No ALL detected)
Presence of ALL-associated genetic markers → Suggests ALL, requiring further evaluation and treatment planning
(Results should be interpreted along with clinical and laboratory findings.)
🎯 Purpose of the Test:
✅ Confirms ALL diagnosis and identifies genetic subtypes
✅ Detects key mutations like BCR-ABL1 (Philadelphia chromosome), KMT2A rearrangements, ETV6-RUNX1 fusion, and TP53 mutations
✅ Assesses risk stratification and prognosis
✅ Guides targeted therapy (e.g., TKIs for BCR-ABL1-positive ALL)
✅ Monitors minimal residual disease (MRD) and relapse risk
🩺 When is it Recommended?
🔹 For suspected ALL cases (abnormal blood counts, fatigue, bruising, frequent infections)
🔹 To determine ALL subtype and best treatment strategy
🔹 For assessing relapse risk and long-term prognosis
🔹 To monitor response to therapy and track disease progression
📝 How is the Test Done?
1️⃣ Sample Collection – Blood or bone marrow sample is taken.
2️⃣ Laboratory Analysis – Techniques like Flow Cytometry, PCR, and Next-Generation Sequencing (NGS) detect genetic mutations and abnormal proteins.
3️⃣ Result Interpretation – Helps classify ALL, guide treatment, and determine prognosis.
⚠️ What Do Abnormal Results Mean?
📉 No ALL-Related Abnormalities Detected:
ALL may not be present, or further tests may be required
📈 ALL-Associated Mutations or Markers Detected:
Confirms ALL diagnosis
Determines risk category (standard vs. high-risk ALL)
Guides personalized treatment approach (e.g., chemotherapy, targeted therapy, immunotherapy)
📌 Infographic Design Idea:
✔ Medical color scheme (blue, white, and green)
✔ Illustration of leukemia cells and genetic markers
✔ Flowchart explaining ALL diagnosis and treatment pathways
✔ Table summarizing key ALL mutations and their clinical significance