🔍 What is the IHC - DOG1 Test?
The DOG1 (Discovered On GIST-1) test is an immunohistochemistry (IHC) test that detects the DOG1 protein in tissue samples. DOG1 is a highly specific marker used to diagnose Gastrointestinal Stromal Tumors (GISTs), a rare type of cancer affecting the digestive tract.
🎯 Purpose of the Test
Doctors may order this test to:
✅ Confirm the diagnosis of GIST
✅ Differentiate GIST from other soft tissue tumors
✅ Guide treatment decisions, especially for targeted therapy
✅ Evaluate tumor progression or recurrence
📊 Normal Ranges
A normal (negative) result means DOG1 protein is not detected, suggesting the tissue is not GIST.
A positive result indicates DOG1 expression, supporting a GIST diagnosis.
(Interpretation should always be done by a pathologist along with clinical findings.)
🔴 Positive DOG1 Expression
Suggests the presence of Gastrointestinal Stromal Tumor (GIST)
May help determine the best course of treatment
🟢 Negative DOG1 Expression
May indicate a different type of tumor
Requires further testing to confirm the diagnosis
🩺 How is the Test Done?
✅ Tissue biopsy is taken from the suspected tumor site.
✅ Immunohistochemistry (IHC) staining is used to detect the DOG1 protein.
✅ No special preparation is needed for the patient.
📌 Consult an oncologist or pathologist for proper diagnosis and treatment planning!